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Article

An integrin β₃-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition.

Nature cell biology - 1 May 2014

Seguin Laetitia, Kato Shumei, Franovic Aleksandra, Camargo M Fernanda, Lesperance Jacqueline, Elliott Kathryn C, Yebra Mayra, Mielgo Ainhoa, Lowy Andrew M, Husain Hatim, Cascone Tina, Diao Lixia, Wang Jing, Wistuba Ignacio I, Heymach John V, Lippman Scott M, Desgrosellier Jay S, Anand Sudarshan, Weis Sara M, Cheresh David A

Abstract excerpt

Tumour cells, with stem-like properties, are highly aggressive and often show drug resistance. Here, we reveal that integrin α(v)β₃ serves as a marker of breast, lung and pancreatic carcinomas with stem-like properties that are highly resistant to receptor tyrosine kinase inhibitors such as erlot...

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Source

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Identifiers

PMID: 24747441
DOI: 10.1038/ncb2953
PMCID: PMC4105198

Genes

KRAS
EGFR
TBK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24747441-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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