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Article

Stemness Phenotype in Tamoxifen Resistant Breast Cancer Cells May be Induced by Interactions Between Receptor Tyrosine Kinases and ERα-66.

Recent patents on anti-cancer drug discovery - 1 Jan 2018

Farahmand Leila, Mansouri Sepideh, Jafarbeik-Iravani Narges, Teymourzadeh Azin, Majidzadeh-A Keivan

Abstract excerpt

BACKGROUND: Tamoxifen is widely administered for patients with estrogen receptor-positive breast cancer. Despite many patients benefiting from Tamoxifen as an effective anti-hormonal agent in adjuvant therapy, a noticeable number of patients tend to develop resistance. OBJECTIVE: The aim of this study was to shed light upon the molecular mechanisms associated with Tamoxifen resistance which can help improve...

Topics

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Antineoplastic Agents, Hormonal
Breast Neoplasms
Drug Resistance, Neoplasm
Estrogen Receptor alpha
MCF-7 Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Patents as Topic

Receptor, ErbB-2

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Identifiers

PMID: 29512469
DOI: 10.2174/1574892813666180305164634

Genes

EGFR
HOXB7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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