Back to search

Article

<i>ITGA2</i> is a target of miR-206 promoting cancer stemness and lung metastasis through enhanced <i>ACLY</i> and <i>CCND1</i> expression in triple negative breast cancer

2019-03-19

Abstract excerpt

Accumulating evidence demonstrates that cancer stemness is essential for both tumor development and progression, regulated by multi-layer factors at genetic, epigenetic and micro-environmental levels. However, how to target stemness-driven plasticity and eliminate metastasis remains one of the biggest challenges in the clinic. We aim to identify novel molecular mechanisms underlying stemness of triple negative bre...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
73de4b67-ff14-5d83-a0e9-631c9973a5f2
DOI
10.1101/583062
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
<i>ITGA2</i> is a target of miR-206 promoting cancer stemness and lung metastasis through enhanced <i>ACLY</i> and <i>CCND1</i> expression in triple negative breast cancerDOI 10.1101/583062
ITGA2 promotes expression of ACLY and CCND1 in enhancing breast cancer stemness and metastasisSemantic proximity
An update on cancer stem cell survival pathways involved in chemoresistance in triple-negative breast cancerSemantic proximity
Cellular stemness identifies high-risk ductal carcinoma <i>in situ</i> and offers a therapeutic interception opportunitySemantic proximity
Low-density lipoprotein receptor promotes crosstalk between cell stemness and tumor immune microenvironment in breast cancer: a large data-based multi-omics studySemantic proximity
Integrating Single-cell and Machine Learning with Experimental Validation Reveals FASN Conferring Breast Cancer Stem cell-like Properties: Therapeutic Insights and Prognostic ImplicationsSemantic proximity
Integrins regulate stemness in solid tumor: an emerging therapeutic target.Semantic proximity
YTHDF1 enhances stemness and chemoresistance in triple‐negative breast cancer cells by upregulating SIAH2Semantic proximity
Decoding the Tumor-Suppressive Landscape of SCARA5: A Network-Based Analysis Linking Lipid Metabolism and Immune Regulation in Breast CancerSemantic proximity
Cell adhesion molecule CD44v10 promotes stem-like properties in triple-negative breast cancer cells via glucose transporter GLUT1-mediated glycolysisSemantic proximity
Deficiency of CCN5/WISP-2-Driven Program in breast cancer Promotes Cancer Epithelial cells to mesenchymal stem cells and Breast Cancer growthSemantic proximity
MiR-4319 Suppress the Malignancy of Triple-Negative Breast Cancer by Regulating Self-Renewal and Tumorigenesis of Stem CellsSemantic proximity
Single-cell RNA sequencing has unveiled the contribution of ADSCs in reprogramming metabolism in triple-negative breast cancerSemantic proximity
Select a neighboring publication to make it the new centre.