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Article

IKKβ Kinase Promotes Stemness, Migration, and Invasion in KRAS-Driven Lung Adenocarcinoma Cells.

International journal of molecular sciences - 13 Aug 2020

Rodrigues Felipe Silva, Miranda Vanessa Silva, Carneiro-Lobo Tatiana Correa, Scalabrini Luiza Coimbra, Kruspig Björn, Levantini Elena, Murphy Daniel J, Bassères Daniela Sanchez

Abstract excerpt

KRAS oncogenic mutations are widespread in lung cancer and, because direct targeting of KRAS has proven to be challenging, KRAS-driven cancers lack effective therapies. One alternative strategy for developing KRAS targeted therapies is to identify downstream targets involved in promoting important malignant features, such as the acquisition of a cancer stem-like and metastatic phenotype. Based on previous studies...

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Source

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Identifiers

PMID: 32823550
DOI: 10.3390/ijms21165806
PMCID: PMC7460870

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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IKKβ Kinase Promotes Stemness, Migration, and Invasion in KRAS-Driven Lung Adenocarcinoma Cells.PMID 32823550Read ↗

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