Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Recent advances in the understanding of mastocytosis: the role of KIT mutations.

British journal of haematology - 1 Jul 2007

Orfao Alberto, Garcia-Montero Andrés C, Sanchez Laura, Escribano Luis

Abstract excerpt

Mastocytosis is a heterogeneous disorder characterised by the expansion and accumulation of mast cells in different organs and tissues. Mast cell physiology is closely dependent on activation of the stem cell factor/Kit signalling pathways and accumulating evidences confirm the physiopathological key role of activating KIT mutations (typically D816V) in mastocytosis and their relationship with the clinical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Benzamides
Share to Cell Survival
Share to Imatinib Mesylate

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mast Cells

Share to Mastocytosis

Share to Piperazines

Share to Proto-Oncogene Proteins c-kit

Share to Pyrimidines

Source

Identifiers

PMID: 17555444
DOI: 10.1111/j.1365-2141.2007.06619.x

Genes

KIT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Recent advances in the understanding of mastocytosis: the role of KIT mutations.PMID 17555444Read ↗

Mastocytosis.Semantic proximity Read ↗

Recent advances in the understanding and therapeutic management of mastocytosisSemantic proximity Read ↗

c-Kit and c-kit mutations in mastocytosis and other hematological diseasesSemantic proximity Read ↗

Molecular defects in mastocytosis: KIT and beyond KIT.Semantic proximity Read ↗

Mastocytosis: from a Molecular Point of View.Semantic proximity Read ↗

Pharmacological targeting of the KIT growth factor receptor: a therapeutic consideration for mast cell disordersSemantic proximity Read ↗

Advanced systemic mastocytosis: the impact of KIT mutations in diagnosis, treatment, and progression.Semantic proximity Read ↗

[Current concepts and treatment advances in systemic mastocytosis].Semantic proximity Read ↗

Functional deregulation of KIT: link to mast cell proliferative diseases and other neoplasms.Semantic proximity Read ↗

<i>KIT</i> and MastocytosisSemantic proximity Read ↗

Tyrosine Kinase Inhibition in Mastocytosis: KIT and Beyond KIT.Semantic proximity Read ↗

KIT mutation in mast cells and other bone marrow hematopoietic cell lineages in systemic mast cell disorders: a prospective study of the Spanish Network on Mastocytosis (REMA) in a series of 113 patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.