Forward-genetics analysis of sleep in randomly mutagenized mice.

doi:10.1038/nature20142

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Article

Forward-genetics analysis of sleep in randomly mutagenized mice.

Nature - 17 Nov 2016

Funato Hiromasa, Miyoshi Chika, Fujiyama Tomoyuki, Kanda Takeshi, Sato Makito, Wang Zhiqiang, Ma Jing, Nakane Shin, Tomita Jun, Ikkyu Aya, Kakizaki Miyo, Hotta-Hirashima Noriko, Kanno Satomi, Komiya Haruna, Asano Fuyuki, Honda Takato, Kim Staci J, Harano Kanako, Muramoto Hiroki, Yonezawa Toshiya, Mizuno Seiya, Miyazaki Shinichi, Connor Linzi, Kumar Vivek, Miura Ikuo, Suzuki Tomohiro, Watanabe Atsushi, Abe Manabu, Sugiyama Fumihiro, Takahashi Satoru, Sakimura Kenji, Hayashi Yu, Liu Qinghua, Kume Kazuhiko, Wakana Shigeharu, Takahashi Joseph S, Yanagisawa Masashi

Abstract excerpt

Sleep is conserved from invertebrates to vertebrates, and is tightly regulated in a homeostatic manner. The molecular and cellular mechanisms that determine the amount of rapid eye movement sleep (REMS) and non-REMS (NREMS) remain unknown. Here we identify two dominant mutations that affect sleep and wakefulness by using an electroencephalogram/electromyogram-based screen of randomly mutagenized mice. A splicing...

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PMID: 27806374
DOI: 10.1038/nature20142
PMCID: PMC6076225

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NALCN
SIK3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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