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Pharmacogenetics of drug metabolizing enzymes in Brazilian populations.

Drug metabolism and drug interactions - 1 Jan 2014

Cerda Alvaro, Hirata Mario Hiroyuki, Hirata Rosario Dominguez Crespo

Abstract excerpt

Phase I and II drug metabolizing enzymes (DMEs) play an important role in biotransformation of endogenous and exogenous compounds including drugs currently used in pharmacoterapy. Moreover, the genetic variability of DMEs causes important interindividual differences in drug and metabolite exposure, drug response, and risk of adverse drug reactions. We reviewed pharmacogenetics/pharmacogenomics (PGx) studies that...

Topics

Arylamine N-Acetyltransferase
Biotransformation
Brazil
Cytochromes
Genetic Variation
Glucuronosyltransferase
Glutathione Transferase
Humans
Methyltransferases
Pharmacogenetics
Polymorphism, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24744305
DOI: 10.1515/dmdi-2013-0067

Genes

NAT2
TPMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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