Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Abnormal elevated PTEN expression in the mouse antrum of a model of GIST Kit(K641E/K641E).

Cellular signalling - 1 Nov 2011

Deneubourg Laurence, Ralea Sebastian, Gromova Petra, Parsons Ramon, Vanderwinden Jean-Marie, Erneux Christophe

Abstract excerpt

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. Approximately 85% of GISTs harbor activating mutations of the KIT or PDGFRA receptor tyrosine kinases. PTEN and SHIP2 are major phosphatases that dephosphorylate PI(3,4,5)P(3), one of the intracellular signal pathways downstream of KIT. PTEN is an important tumor suppressor, whereas the involvement of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Benzamides
Share to Gastrointestinal Stromal Tumors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Knock-In Techniques

Share to Imatinib Mesylate

Share to Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases

Share to Phosphoric Monoester Hydrolases

Share to Piperazines

Share to PTEN Phosphohydrolase

Source

Identifiers

PMID: 21757001
DOI: 10.1016/j.cellsig.2011.06.023

Genes

PTEN
KIT
PDGFRA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Abnormal elevated PTEN expression in the mouse antrum of a model of GIST Kit(K641E/K641E).PMID 21757001Read ↗

Kit K641E oncogene up-regulates Sprouty homolog 4 and trophoblast glycoprotein in interstitial cells of Cajal in a murine model of gastrointestinal stromal tumours.Semantic proximity Read ↗

A knock-in mouse model of gastrointestinal stromal tumor harboring kit K641E.Semantic proximity Read ↗

PTEN: from pathology to biology.Semantic proximity Read ↗

Gastrointestinal stromal tumors in a mouse model by targeted mutation of the Kit receptor tyrosine kinaseSemantic proximity Read ↗

Gain-of-Function Mutations of Receptor Tyrosine Kinases in Gastrointestinal Stromal TumorsSemantic proximity Read ↗

Direct engagement of the PI3K pathway by mutant KIT dominates oncogenic signaling in gastrointestinal stromal tumor.Semantic proximity Read ↗

Frequent mono-allelic loss associated with deficient PTEN expression in imatinib-resistant gastrointestinal stromal tumors.Semantic proximity Read ↗

Recent advances in PTEN signalling axes in cancerSemantic proximity Read ↗

Imatinib resistance and microcytic erythrocytosis in a KitV558Δ;T669I/+ gatekeeper-mutant mouse model of gastrointestinal stromal tumor.Semantic proximity Read ↗

ETV1-Positive Cells Give Rise to BRAFV600E -Mutant Gastrointestinal Stromal Tumors.Semantic proximity Read ↗

Portrait of PTEN: messages from mutant mice.Semantic proximity Read ↗

An activating mutation in the PDGF receptor-beta causes abnormal morphology in the mouse placenta.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.