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Article

Capturing the biological impact of CDKN2A and MC1R genes as an early predisposing event in melanoma and non melanoma skin cancer.

Oncotarget - 30 Mar 2014

Puig-Butille Joan Anton, Escámez María José, Garcia-Garcia Francisco, Tell-Marti Gemma, Fabra Àngels, Martínez-Santamaría Lucía, Badenas Celia, Aguilera Paula, Pevida Marta, Dopazo Joaquín, del Río Marcela, Puig Susana

Abstract excerpt

Germline mutations in CDKN2A and/or red hair color variants in MC1R genes are associated with an increased susceptibility to develop cutaneous melanoma or non melanoma skin cancer. We studied the impact of the CDKN2A germinal mutation p.G101W and MC1R variants on gene expression and transcription profiles associated with skin cancer. To this end we set-up primary skin cell co-cultures from siblings of melanoma...

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Share to Carcinoma, Squamous Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p16

Share to Keratinocytes

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Share to Melanoma, Cutaneous Malignant

Share to Receptor, Melanocortin, Type 1

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Source

Open in PubMed Open full text

Identifiers

PMID: 24742402
DOI: 10.18632/oncotarget.1444
PMCID: PMC4039222

Genes

IFI27
IFI44
IFNK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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