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Article

MC1R variants predisposing to concomitant primary cutaneous melanoma in a monozygotic twin pair.

BMC medical genetics - 14 Sept 2012

Pellegrini Cristina, Fargnoli Maria Concetta, Suppa Mariano, Peris Ketty

Abstract excerpt

BACKGROUND: Concomitant primary cutaneous melanoma in monozygotic twins has been reported in only two pairs but in neither of them genetic analysis was performed. Two high-penetrance susceptibility genes, CDKN2A and CDK4 and one low-penetrance gene, MC1R, are well-defined genetic risk factors for melanoma. MITF has been recently identified as a novel intermediate risk melanoma-predisposing gene. CASE...

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Source

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Identifiers

PMID: 22978401
DOI: 10.1186/1471-2350-13-81
PMCID: PMC3483249

Genes

CDK4
MITF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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