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Article

The role of CYP3A5 genotypes in dose requirements of tacrolimus and everolimus after heart transplantation.

Clinical transplantation - 1 Jan 2000

Kniepeiss Daniela, Renner Wilfried, Trummer Olivia, Wagner Doris, Wasler Andrä, Khoschsorur Gholam A, Truschnig-Wilders Martie, Tscheliessnigg Karl-Heinz

Abstract excerpt

BACKGROUND: tacrolimus and everolimus are immunosuppressive drugs metabolized by enzymes of the CYP3A subfamily. A common variant of the CYP3A5 gene, CYP3A5*3, results in strongly decreased CYP3A5 activity and has been shown to influence Tacrolimus blood concentrations, but its role for the pharm...

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Source

Identifiers

PMID: 20041908
DOI: 10.1111/j.1399-0012.2009.01198.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20041908-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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