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Article

LRP1 is a receptor for <i>Clostridium perfringens</i> TpeL toxin indicating a two-receptor model of clostridial glycosylating toxins

15 Apr 2014

Abstract excerpt

Large glycosylating toxins are major virulence factors of various species of pathogenic Clostridia. Prototypes are Clostridium difficile toxins A and B, which cause antibiotics-associated diarrhea and pseudomembranous colitis. The current model of the toxins' action suggests that receptor binding is mediated by a C-terminal domain of combined repetitive oligopeptides (CROP). This model is challenged by the...

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PMID: 24737893
DOI: 10.1073/pnas.1323790111

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