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Article

Characterization of putative cholesterol recognition/interaction amino acid consensus-like motif of Campylobacter jejuni cytolethal distending toxin C.

PloS one - 1 Jan 2013

Lai Chih-Ho, Lai Cheng-Kuo, Lin Ying-Ju, Hung Chiu-Lien, Chu Chia-Han, Feng Chun-Lung, Chang Chia-Shuo, Su Hong-Lin

Abstract excerpt

Cytolethal distending toxin (CDT) produced by Campylobacter jejuni comprises a heterotrimeric complex formed by CdtA, CdtB, and CdtC. Among these toxin subunits, CdtA and CdtC function as essential proteins that mediate toxin binding to cytoplasmic membranes followed by delivery of CdtB into the nucleus. The binding of CdtA/CdtC to the cell surface is mediated by cholesterol, a major component in lipid rafts....

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Identifiers

PMID: 23762481
DOI: 10.1371/journal.pone.0066202
PMCID: PMC3675143

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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