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Article

Genetic and infectious profiles influence cerebrospinal fluid IgG abnormality in Japanese multiple sclerosis patients.

PloS one - 1 Jan 2014

Yoshimura Satoshi, Isobe Noriko, Matsushita Takuya, Masaki Katsuhisa, Sato Shinya, Kawano Yuji, Ochi Hirofumi, Kira Jun-Ichi

Abstract excerpt

BACKGROUND: Abnormal intrathecal synthesis of IgG, reflected by cerebrospinal fluid (CSF) oligoclonal IgG bands (OBs) and increased IgG index, is much less frequently observed in Japanese multiple sclerosis (MS) cohorts compared with Western cohorts. We aimed to clarify whether genetic and common infectious backgrounds influence CSF IgG abnormality in Japanese MS patients. METHODOLOGY: We analyzed HLA-DRB1...

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PMID: 24736746
DOI: 10.1371/journal.pone.0095367
PMCID: PMC3988235

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