Article

TNF-TNFR Signaling Modality Conserved Across Invertebrate

2024-07-29

Abstract excerpt

<h4>ABSTRACT</h4> In humans, the signaling mechanisms of the 19 paralogs of the tumor necrosis factor superfamily (TNFSF) and the 29 receptor paralogs of the tumor necrosis factor receptor superfamily (TNFRSF) are extensively characterized because of their therapeutic relevance. The functional expansion of TNFSF in vertebrates from a single ancestral gene through successive duplication events is also well establi...

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Literature Corpus work: 4d441866-5903-5c44-bacb-b491fd37c439
DOI: 10.1101/2024.07.27.603686

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