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Article

Functional disruption of yeast metacaspase, Mca1, leads to miltefosine resistance and inability to mediate miltefosine-induced apoptotic effects.

Fungal genetics and biology : FG & B - 1 Jun 2014

Biswas Chayanika, Zuo Xiaoming, Chen Sharon C-A, Schibeci Stephen D, Forwood Jade K, Jolliffe Katrina A, Sorrell Tania C, Djordjevic Julianne T

Abstract excerpt

Miltefosine (MI) is a novel, potential antifungal agent with activity against some yeast and filamentous fungal pathogens. We previously demonstrated in the model yeast, Saccharomyces cerevisiae, that MI causes disruption of mitochondrial membrane potential and apoptosis-like cell death via interaction with the Cox9p sub-unit of cytochrome c oxidase (COX). To identify additional mechanisms of antifungal action,...

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PMID: 24731805
DOI: 10.1016/j.fgb.2014.04.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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