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Amino acid-derived 1,2-benzisothiazolinone derivatives as novel small-molecule antifungal inhibitors: identification of potential genetic targets.

Antimicrobial agents and chemotherapy - 1 Sept 2012

Alex Deepu, Gay-Andrieu Francoise, May Jared, Thampi Linta, Dou Dengfeng, Mooney Aileen, Groutas William, Calderone Richard

Abstract excerpt

We have identified four synthetic compounds (DFD-VI-15, BD-I-186, DFD-V-49, and DFD-V-66) from an amino acid-derived 1,2-benzisothiazolinone (BZT) scaffold that have reasonable MIC(50) values against a panel of fungal pathogens. These compounds have no structural similarity to existing antifungal drugs. Three of the four compounds have fungicidal activity against Candida spp., Cryptococcus neoformans, and several...

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Arthrodermataceae
Aspergillus fumigatus
Cryptococcus neoformans
Drug Resistance, Multiple, Fungal
Glycerol

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Membrane Potential, Mitochondrial

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PMID: 22687516
DOI: 10.1128/AAC.00477-12
PMCID: PMC3421843

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