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Article

Inactivation of Cdc13p triggers MEC1-dependent apoptotic signals in yeast.

The Journal of biological chemistry - 25 Apr 2003

Qi Haiyan, Li Tsai-Kun, Kuo Debbie, Nur-E-Kamal Alam, Liu Leroy F

Abstract excerpt

Inactivation of the budding yeast telomere binding protein Cdc13 results in abnormal telomeres (exposed long G-strands) and activation of the DNA damage checkpoint. In the current study, we show that inactivation of Cdc13p induces apoptotic signals in yeast, as evidenced by caspase activation, increased reactive oxygen species production, and flipping of phosphatidylserine in the cytoplasmic membrane. These...

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Source

Identifiers

PMID: 12569108
DOI: 10.1074/jbc.M212808200

Genes

MRE11

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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