Article
Association of BDNF promoter methylation and genotype with suicidal ideation in elderly Koreans.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry - 1 Oct 2014
Kim Jae-Min, Kang Hee-Ju, Bae Kyung-Yeol, Kim Sung-Wan, Shin Il-Seon, Kim Hye-Ran, Shin Myung-Geun, Yoon Jin-Sang
Abstract excerpt
OBJECTIVES: Brain-derived neurotrophic factor (BDNF) has been considered a risk factor for suicidal behavior in adult populations. BDNF secretion is influenced by epigenetic (DNA promoter methylation) and genetic (val66met polymorphism) profiles. We investigated the independent and interactive effects of BDNF methylation status and val66met polymorphisms on late-life suicidal ideation. METHODS: In total, 732...
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