Article
BDNF promoter methylation associated with suicidal ideation in patients with breast cancer.
International journal of psychiatry in medicine - 1 Jan 2015
Kim Jae-Min, Kang Hee-Ju, Kim Seon-Young, Kim Sung-Wan, Shin Il-Seon, Kim Hye-Ran, Park Min-Ho, Shin Myung-Geun, Yoon Jung-Han, Yoon Jin-Sang
Abstract excerpt
OBJECTIVE: Brain-derived neurotrophic factor (BDNF) has been considered a risk factor for suicidality. BDNF secretion is influenced by epigenetic (DNA methylation) and genetic (val66met polymorphism) profiles. We aimed to investigate the independent effects of BDNF promoter methylation status on suicidal ideation as well as the effects of its interaction with the val66met polymorphism in patients with breast...
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