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The brain-derived neurotrophic factor gene in suicidal behaviour: a meta-analysis.

The international journal of neuropsychopharmacology - 1 Sept 2012

Zai Clement C, Manchia Mirko, De Luca Vincenzo, Tiwari Arun K, Chowdhury Nabilah I, Zai Gwyneth C, Tong Ryan P, Yilmaz Zeynep, Shaikh Sajid A, Strauss John, Kennedy James L

Abstract excerpt

Suicide is a prominent public health problem. Its aetiology is complex, and the brain-derived neurotrophic factor (BDNF) has been implicated. We performed the first meta-analysis of the functional BDNF marker Val⁶⁶Met (rs6265, 196G>A) in suicidal behaviour using data from 11 previously published samples plus our present sample (total n=3352 subjects, 1202 with history of suicidal behaviour. The meta-analysis...

Topics

Brain-Derived Neurotrophic Factor
Gene Frequency
Genotype
Humans
Methionine
Odds Ratio
Suicide
Valine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21875455
DOI: 10.1017/S1461145711001313

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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