Article
Activation of p53 in Down Syndrome and in the Ts65Dn Mouse Brain is Associated with a Pro-Apoptotic Phenotype.
Journal of Alzheimer's disease : JAD - 1 Jan 2016
Tramutola Antonella, Pupo Gilda, Di Domenico Fabio, Barone Eugenio, Arena Andrea, Lanzillotta Chiara, Brokeaart Diede, Blarzino Carla, Head Elizabeth, Butterfield D Allan, Perluigi Marzia
Abstract excerpt
Down syndrome (DS) is the most common genetic cause of intellectual disability, resulting from trisomy of chromosome 21. The main feature of DS neuropathology includes early onset of Alzheimer's disease (AD), with deposition of senile plaques and tangles. We hypothesized that apoptosis may be activated in the presence of AD neuropathology in DS, thus we measured proteins associated with upstream and downstream...
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