Article
Pharmacogenetics and pharmagenomics, trends in normal and pathological aging studies: focus on p53.
Current pharmaceutical design - 1 Jan 2008
Lanni C, Racchi M, Uberti D, Mazzini G, Stanga S, Sinforiani E, Memo M, Govoni S
Abstract excerpt
In spite of the fact that the aging organism is the result of complex life-long gene/environment interactions, making peculiar the susceptibility to diseases and the response to drugs, pharmacogenetics studies are largely neglected in the aged. Altered response to drugs, cardiovascular and metabolic alterations, cancer and dementia are among the age associated ailments. The latter two are the major contributors...
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