Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs.

doi:10.1016/s1097-2765(00)80006-4

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Article

Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs.

Molecular cell - 1 Dec 1997

Rawson R B, Zelenski N G, Nijhawan D, Ye J, Sakai J, Hasan M T, Chang T Y, Brown M S, Goldstein J L

Abstract excerpt

We report the cloning of a gene, S2P, that encodes a putative metalloprotease required for intramembrane proteolysis of sterol-regulatory element-binding proteins (SREBPs) at Site-2. SREBPs are membrane-bound transcription factors that activate genes regulating cholesterol metabolism. The active...

Topics

Animals
CCAAT-Enhancer-Binding Proteins
CHO Cells
Cloning, Molecular
Cricetinae
DNA Mutational Analysis
DNA, Complementary
DNA-Binding Proteins
Endopeptidases
Gene Expression Regulation, Enzymologic
Genes, Reporter
Genetic Complementation Test
Humans
Luciferases

Source

Open in PubMed

Identifiers

PMID: 9659902
DOI: 10.1016/s1097-2765(00)80006-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9659902-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Membrane Proteins

Metalloendopeptidases

Molecular Sequence Data

Mutation