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Article

ACE2 gene expression is up-regulated in the human failing heart

19 May 2004

Abstract excerpt

BACKGROUND: ACE2 is a novel homologue of angiotensin converting enzyme (ACE). ACE2 is highly expressed in human heart and animal data suggest that ACE2 is an essential regulator of cardiac function in vivo. Since overactivity of the renin-angiotensin system contributes to the progression of heart failure, this investigation assessed changes in gene expression of ACE2, ACE, AT1 receptor and renin in the human...

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Share to Heart Failure Treatment and Management
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PMID: 15151696
DOI: 10.1186/1741-7015-2-19

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