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Article

The effect of interleukin-8 truncations on its interactions with glycosaminoglycans.

Biopolymers - 1 Aug 2018

Nordsieck Karoline, Baumann Lars, Hintze Vera, Pisabarro M Teresa, Schnabelrauch Matthias, Beck-Sickinger Annette G, Samsonov Sergey A

Abstract excerpt

The chemokine interleukin-8 (IL-8, CXCL8) plays an important role in inflammatory processes and consecutive wound healing. It recruits primarily neutrophils to infection sites and stimulates their degranulation and phagocytosis in effector cells. IL-8 binds glycosaminoglycans (GAGs), a class of complex linear anionic polysaccharides often organized into diversely sulfated micro-domains, that enriches the protein...

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Identifiers

PMID: 29377072
DOI: 10.1002/bip.23103

Genes

CXCL8

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