Article
ARF and p53 coordinate tumor suppression of an oncogenic IFN-β-STAT1-ISG15 signaling axis.
Cell reports - 24 Apr 2014
Forys Jason T, Kuzmicki Catherine E, Saporita Anthony J, Winkeler Crystal L, Maggi Leonard B, Weber Jason D
Abstract excerpt
The ARF and p53 tumor suppressors are thought to act in a linear pathway to prevent cellular transformation in response to various oncogenic signals. Here, we show that loss of p53 leads to an increase in ARF protein levels, which function to limit the proliferation and tumorigenicity of p53-defi...
Topics
- ADP-Ribosylation Factors
- Animals
- Breast Neoplasms
- Cell Line
- Cell Proliferation
- Cells, Cultured
- Cytokines
- Female
- Humans
- Interferon-beta
- Mice
- Mutation
- STAT1 Transcription Factor
- Signal Transduction
- Tumor Suppressor Protein p53
- Ubiquitins