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Article

Methylenetetrahydrofolate reductase gene variants and antipsychotic-induced weight gain and metabolic disturbances.

Journal of psychiatric research - 1 Jul 2014

Kao A C C, Rojnic Kuzman M, Tiwari A K, Zivkovic M V, Chowdhury N I, Medved V, Kekin I, Zai C C, Lieberman J A, Meltzer H Y, Bozina T, Bozina N, Kennedy J L, Sertic J, Müller D J

Abstract excerpt

Weight gain and metabolic disturbances represent serious side-effects in antipsychotic (AP) treatment, particularly with clozapine and olanzapine. The methylenetetrahydrofolate reductase (MTHFR) gene is a key determinant in the folate metabolism and previous studies reported a significant effect...

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Source

Identifiers

PMID: 24725652
DOI: 10.1016/j.jpsychires.2014.03.012

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24725652-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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