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Fat Mass and Obesity-Related Gene Variants rs9939609 and rs7185735 are Associated with Second-Generation Antipsychotic-Induced Weight Gain.

Pharmacopsychiatry - 1 Jan 2019

Schröder Charlotte, Czerwensky Fabian, Leucht Stefan, Steimer Werner

Abstract excerpt

INTRODUCTION: Weight gain is a limiting and frequent adverse effect of second-generation antipsychotic therapy. Identifying genetic risk factors would significantly improve pharmacotherapy. METHODS: We focused on rs7185735 and rs9939609, 2 common single nucleotide polymorphisms of the fat mass and obesity-associated (FTO) gene reported to be associated with obesity. Three-hundred fifty Caucasian inpatients were...

Topics

Adipose Tissue
Adult
Alleles
Alpha-Ketoglutarate-Dependent Dioxygenase FTO
Antipsychotic Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Female

Genetic Predisposition to Disease

Humans

Male

Organ Size

Polymorphism, Single Nucleotide

Receptor, Melanocortin, Type 4

Weight Gain

White People

Young Adult

Source

Identifiers

PMID: 29334686
DOI: 10.1055/s-0043-125392

Genes

FTO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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