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Article

MC4R rs489693: a clinical risk factor for second generation antipsychotic-related weight gain?

The international journal of neuropsychopharmacology - 1 Oct 2013

Czerwensky Fabian, Leucht Stefan, Steimer Werner

Abstract excerpt

Weight gain is a therapy limiting and very frequent adverse effect of many second-generation antipsychotic (SGA) drugs. The human melanocortin four receptor (MC4R) is a very promising candidate gene possibly influencing SGA-related weight gain. The rs489693 polymorphism near the MC4R gene was associated with SGA-related weight gain in a genome-wide association study. We tried to replicate these results in our...

Topics

Adult
Analysis of Variance
Antipsychotic Agents
Chi-Square Distribution
Female
Gene Frequency
Homozygote
Humans
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Pharmacogenetics

Phenotype

Polymorphism, Genetic

Receptor, Melanocortin, Type 4

Retrospective Studies

Risk Factors

Time Factors

Weight Gain

Source

Identifiers

PMID: 23920449
DOI: 10.1017/S1461145713000849

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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