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Article

MTHFR genotype and differential evolution of metabolic parameters after initiation of a second generation antipsychotic: an observational study.

International clinical psychopharmacology - 1 Sept 2010

van Winkel Ruud, Moons Tim, Peerbooms Odette, Rutten Bart, Peuskens Joseph, Claes Stephan, van Os Jim, De Hert Marc

Abstract excerpt

Most second-generation antipsychotics (SGAs) induce metabolic disturbances, but large differences exist in the degree to which individual patients develop these. Little is known about genetic factors associated with differential liability. Cross-sectional studies suggested an association between polymorphisms in 5,10-methylenetetraydrofolate reductase (MTHFR) and metabolic syndrome in patients with schizophrenia....

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Source

Identifiers

PMID: 20523222
DOI: 10.1097/YIC.0b013e32833bc60d

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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