Article
Proteome-wide analysis of single-nucleotide variations in the N-glycosylation sequon of human genes.
PloS one - 1 Jan 2012
Mazumder Raja, Morampudi Krishna Sudeep, Motwani Mona, Vasudevan Sona, Goldman Radoslav
Abstract excerpt
N-linked glycosylation is one of the most frequent post-translational modifications of proteins with a profound impact on their biological function. Besides other functions, N-linked glycosylation assists in protein folding, determines protein orientation at the cell surface, or protects proteins from proteases. The N-linked glycans attach to asparagines in the sequence context Asn-X-Ser/Thr, where X is any amino...
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