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Proteomics analysis of melanoma metastases: association between S100A13 expression and chemotherapy resistance

10 Apr 2014

Abstract excerpt

BACKGROUND: Disseminated cutaneous malignant melanoma (CMM) is commonly unresponsive to standard chemotherapies, and there are as yet no predictive markers of therapy response. METHODS: In the present study we collected fresh-frozen pretreatment lymph-node metastasis samples (n=14) from melanoma patients with differential response to dacarbazine (DTIC) or temozolomide (TMZ) chemotherapy, to identify proteins with...

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PMID: 24722184
DOI: 10.1038/bjc.2014.169

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