Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Complex Role for Lipocalin 2 in Bone Metabolism: Global Ablation in Mice Induces Osteopenia Caused by an Altered Energy Metabolism.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jun 2018

Capulli Mattia, Ponzetti Marco, Maurizi Antonio, Gemini-Piperni Sara, Berger Thorsten, Mak Tak Wah, Teti Anna, Rucci Nadia

Abstract excerpt

Lipocalin 2 (Lcn2) is an adipokine that carries out a variety of functions in diverse organs. We investigated the bone phenotype and the energy metabolism of Lcn2 globally deleted mice (Lcn2-/- ) at different ages. Lcn2-/- mice were largely osteopenic, exhibiting lower trabecular bone volume, lesser trabecular number, and higher trabecular separation when compared to wild-type (WT) mice. Lcn2-/- mice showed a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adiposity
Share to Bone Diseases, Metabolic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bone Remodeling

Share to Glucose Transporter Type 1

Share to Gonads

Share to Lipocalin-2

Share to Osteoblasts

Share to Osteoclasts

Source

Identifiers

PMID: 29444358
DOI: 10.1002/jbmr.3406

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Complex Role for Lipocalin 2 in Bone Metabolism: Global Ablation in Mice Induces Osteopenia Caused by an Altered Energy Metabolism.PMID 29444358Read ↗

Lipocalin-2 Regulates Osteocyte Ferroptosis and Osteocyte-Osteoblast Crosstalk via Wnt Signaling to Control Bone FormationSemantic proximity Read ↗

A minor role for lipocalin 2 in high-fat diet-induced glucose intolerance.Semantic proximity Read ↗

Lipocalin 2: a new mechanoresponding gene regulating bone homeostasis.Semantic proximity Read ↗

Lipocalin 2 Influences Bone and Muscle Phenotype in the MDX Mouse Model of Duchenne Muscular Dystrophy.Semantic proximity Read ↗

Lipocalin-2 deficiency impairs thermogenesis and potentiates diet-induced insulin resistance in mice.Semantic proximity Read ↗

ASXL2 Regulates Glucose, Lipid, and Skeletal HomeostasisSemantic proximity Read ↗

Osteocalcin-dependent and -independent metabolic dysregulation in a mouse model of Osteogenesis imperfecta.Semantic proximity Read ↗

Integrated Phenotypic and Transcriptomic Analyses of Osteoporosis in Type 2 Diabetic MiceSemantic proximity Read ↗

LCN2 overexpression in bone enhances the hematopoietic compartment via modulation of the bone marrow microenvironment.Semantic proximity Read ↗

In C57Bl6 Mice, Obesity and Subsequent Weight Loss Negatively Affected the Skeleton and Shifted the Cortical Bone MetabolomeSemantic proximity Read ↗

Expression Analysis of Lipocalin 2 (LCN2) in Reproductive and Non-Reproductive Tissues of Esr1-Deficient MiceSemantic proximity Read ↗

Metabolic phenotypes in a Lyz2Cre recombinase mouse modelSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.