Article
Mitochondrial impairment observed in fibroblasts from South African Parkinson's disease patients with parkin mutations.
Biochemical and biophysical research communications - 2 May 2014
van der Merwe Celia, Loos Ben, Swart Chrisna, Kinnear Craig, Henning Franclo, van der Merwe Lize, Pillay Komala, Muller Nolan, Zaharie Dan, Engelbrecht Lize, Carr Jonathan, Bardien Soraya
Abstract excerpt
Parkinson's disease (PD), defined as a neurodegenerative disorder, is characterized by the loss of dopaminergic neurons in the substantia nigra in the midbrain. Loss-of-function mutations in the parkin gene are a major cause of autosomal recessive, early-onset PD. Parkin has been implicated in the maintenance of healthy mitochondria, although previous studies show conflicting findings regarding mitochondrial...
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