Article
Mutant Parkin impairs mitochondrial function and morphology in human fibroblasts.
PloS one - 27 Sept 2010
Grünewald Anne, Voges Lisa, Rakovic Aleksandar, Kasten Meike, Vandebona Himesha, Hemmelmann Claudia, Lohmann Katja, Orolicki Slobodanka, Ramirez Alfredo, Schapira Anthony H V, Pramstaller Peter P, Sue Carolyn M, Klein Christine
Abstract excerpt
BACKGROUND: Mutations in Parkin are the most common cause of autosomal recessive Parkinson disease (PD). The mitochondrially localized E3 ubiquitin-protein ligase Parkin has been reported to be involved in respiratory chain function and mitochondrial dynamics. More recent publications also described a link between Parkin and mitophagy. METHODOLOGY/PRINCIPAL FINDINGS: In this study, we investigated the impact of...
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