Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mitochondrial dysfunction in Parkinson disease: evidence in mutant PARK2 fibroblasts

11 Mar 2015

Abstract excerpt

Mutations in PARK2, encoding Parkin, cause an autosomal recessive form of juvenile Parkinson Disease (JPD). The aim of the present study was to investigate the impact of PARK2 mutations on mitochondrial function and morphology in human skin fibroblasts. We analyzed cells obtained from four patients clinically characterized by JPD, harboring recessive mutations in PARK2. By quantitative PCR we found a reduction...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Autophagy in Disease and Therapy
Share to Parkinson's Disease Mechanisms and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25815004
DOI: 10.3389/fgene.2015.00078

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitochondrial dysfunction in Parkinson disease: evidence in mutant PARK2 fibroblastsPMID 25815004Read ↗

Mutant Parkin impairs mitochondrial function and morphology in human fibroblasts.Semantic proximity Read ↗

Altered Mitochondrial Respiration and Other Features of Mitochondrial Function inParkin-Mutant Fibroblasts from Parkinson’s Disease PatientsSemantic proximity Read ↗

Exploring the Impact of PARK2 Mutations on the Total and Mitochondrial Proteome of Human Skin FibroblastsSemantic proximity Read ↗

Mitochondrial defect and PGC-1α dysfunction in parkin-associated familial Parkinson's disease.Semantic proximity Read ↗

Mitochondrial function and morphology are impaired in parkin-mutant fibroblasts.Semantic proximity Read ↗

The Charcot-Marie Tooth Disease Mutation R94Q in MFN2 Decreases ATP Production but Increases Mitochondrial Respiration under Conditions of Mild Oxidative Stress.Semantic proximity Read ↗

Mitochondrial impairment observed in fibroblasts from South African Parkinson's disease patients with parkin mutations.Semantic proximity Read ↗

The Charcot Marie Tooth Disease Mutation R94Q in MFN2 Decreases ATP Production but Increases Mitochondrial Respiration under Conditions of Mild Oxidative StressSemantic proximity Read ↗

PARK2 Mutation Causes Metabolic Disturbances and Impaired Survival of Human iPSC-Derived NeuronsSemantic proximity Read ↗

Oxidative switch drives mitophagy defects in dopaminergic parkin mutant patient neuronsSemantic proximity Read ↗

Mitochondrial impairment in patients with Parkinson disease with the G2019S mutation in LRRK2.Semantic proximity Read ↗

Impaired Mitochondrial Network Morphology and ROS production in Fibroblasts from Parkinson’s Disease PatientsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.