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Article

Primary Skin Fibroblasts as a Model of Parkinson's Disease

18 Feb 2012

Abstract excerpt

Parkinson's disease is the second most frequent neurodegenerative disorder. While most cases occur sporadic mutations in a growing number of genes including Parkin (PARK2) and PINK1 (PARK6) have been associated with the disease. Different animal models and cell models like patient skin fibroblasts and recombinant cell lines can be used as model systems for Parkinson's disease. Skin fibroblasts present a system...

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PMID: 22350618
DOI: 10.1007/s12035-012-8245-1

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