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Article

Mitochondrial function and morphology are impaired in parkin-mutant fibroblasts.

Annals of neurology - 1 Nov 2008

Mortiboys Heather, Thomas Kelly Jean, Koopman Werner J H, Klaffke Stefanie, Abou-Sleiman Patrick, Olpin Simon, Wood Nicholas W, Willems Peter H G M, Smeitink Jan A M, Cookson Mark R, Bandmann Oliver

Abstract excerpt

OBJECTIVE: There are marked mitochondrial abnormalities in parkin-knock-out Drosophila and other model systems. The aim of our study was to determine mitochondrial function and morphology in parkin-mutant patients. We also investigated whether pharmacological rescue of impaired mitochondrial function may be possible in parkin-mutant human tissue. METHODS: We used three sets of techniques, namely, biochemical...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Membrane Potential, Mitochondrial

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Identifiers

PMID: 19067348
DOI: 10.1002/ana.21492
PMCID: PMC2613566

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