Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Elevated plasma factor VIII in a mouse model of low-density lipoprotein receptor-related protein deficiency.

Blood - 15 May 2003

Bovenschen Niels, Herz Joachim, Grimbergen Jos M, Lenting Peter J, Havekes Louis M, Mertens Koen, van Vlijmen Bart J M

Abstract excerpt

It has been established that low-density lipoprotein receptor-related protein (LRP) is involved in the cellular uptake and degradation of coagulation factor VIII (FVIII) in vitro. To address the physiologic role of LRP in regulating plasma FVIII in vivo, we used cre/loxP-mediated conditional LRP- deficient mice (MX1cre(+)LRP(flox/flox)). Upon inactivation of the LRP gene, MX1cre(+)LRP(flox/flox) mice had...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoviridae
Share to Factor VIII

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Transfer Techniques

Share to Genetic Vectors

Share to Kinetics

Share to Low Density Lipoprotein Receptor-Related Protein-2

Share to Mice, Inbred Strains

Share to von Willebrand Factor

Source

Identifiers

PMID: 12522008
DOI: 10.1182/blood-2002-07-2081

Genes

VWF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Elevated plasma factor VIII in a mouse model of low-density lipoprotein receptor-related protein deficiency.PMID 12522008Read ↗

Murine coagulation factor VIII is synthesized in endothelial cellsSemantic proximity Read ↗

Altered phenotype in LMAN1-deficient mice with low levels of residual LMAN1 expression.Semantic proximity Read ↗

Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of α1-antitrypsin.Semantic proximity Read ↗

A conditional knockout mouse model reveals endothelial cells as the principal and possibly exclusive source of plasma factor VIII.Semantic proximity Read ↗

Cre/lox Studies Identify Resident Macrophages as the Major Source of Circulating Coagulation Factor XIII-A.Semantic proximity Read ↗

Sustained somatic gene inactivation by viral transfer of Cre recombinase.Semantic proximity Read ↗

Mutant Lrp1 knock-in mice generated by recombinase-mediated cassette exchange reveal differential importance of the NPXY motifs in the intracellular domain of LRP1 for normal fetal development.Semantic proximity Read ↗

Rescue of Fatal Neonatal Hemorrhage in Factor V Deficient Mice by Low Level Transgene ExpressionSemantic proximity Read ↗

Tissue factor deficiency causes cardiac fibrosis and left ventricular dysfunction.Semantic proximity Read ↗

Inactivation of the LRP1 intracellular NPxYxxL motif in LDLR-deficient mice enhances postprandial dyslipidemia and atherosclerosis.Semantic proximity Read ↗

Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants.Semantic proximity Read ↗

Mapping the binding region on the low density lipoprotein receptor for blood coagulation factor VIII.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.