Article
Neurolysin knockout mice generation and initial phenotype characterization.
The Journal of biological chemistry - 30 May 2014
Cavalcanti Diogo M L P, Castro Leandro M, Rosa Neto José C, Seelaender Marilia, Neves Rodrigo X, Oliveira Vitor, Forti Fábio L, Iwai Leo K, Gozzo Fabio C, Todiras Mihail, Schadock Ines, Barros Carlos C, Bader Michael, Ferro Emer S
Abstract excerpt
The oligopeptidase neurolysin (EC 3.4.24.16; Nln) was first identified in rat brain synaptic membranes and shown to ubiquitously participate in the catabolism of bioactive peptides such as neurotensin and bradykinin. Recently, it was suggested that Nln reduction could improve insulin sensitivity. Here, we have shown that Nln KO mice have increased glucose tolerance, insulin sensitivity, and gluconeogenesis. KO...
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