Article

Macronutrient Composition and Genetic Background Determine the Response to a Ketogenic Diet

2026-04-27

Abstract excerpt

While standard high fat diets cause hyperphagia and obesity in mice, high fat-low carbohydrate ketogenic diets (KDs) reduce food intake and body weight. Because the basis for this difference is still unclear, we systematically altered the macronutrient content of a standard KD and found that feeding C57BL/6J (B6J) mice a KD with 5% protein resulted in hypophagia, weight loss, and hypoglycemia, whereas the same die...

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Identifiers and source

Literature Corpus work: 02db5749-a487-551d-9750-3cbc4969c825
DOI: 10.64898/2026.04.23.720368

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