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Article

The Wnt signalling cascade and the adherens junction complex in craniopharyngioma tumorigenesis.

Endocrine pathology - 1 Mar 2015

Preda Veronica, Larkin Sarah J, Karavitaki Niki, Ansorge Olaf, Grossman Ashley B

Abstract excerpt

Craniopharyngiomas are epithelial, sellar tumours with adamantinomatous (aCP) and papillary (pCP) subtypes. The aCP type usually occurs during childhood and pCP in middle-aged adults; aCPs often contain mutations in CTNNB1, encoding β-catenin, a component of the adherens junction and a mediator of Wnt signalling. No such mutational event has been associated with pCPs, where the BRAF gene appears to be more...

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Source

Identifiers

PMID: 25355426
DOI: 10.1007/s12022-014-9341-8

Genes

CTNNB1
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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