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Article

Defects in phosphate acquisition and storage influence virulence of Cryptococcus neoformans.

Infection and immunity - 1 Jul 2014

Kretschmer Matthias, Reiner Ethan, Hu Guanggan, Tam Nicola, Oliveira Debora L, Caza Melissa, Yeon Ju Hun, Kim Jeongmi, Kastrup Christian J, Jung Won Hee, Kronstad James W

Abstract excerpt

Nutrient acquisition and sensing are critical aspects of microbial pathogenesis. Previous transcriptional profiling indicated that the fungal pathogen Cryptococcus neoformans, which causes meningoencephalitis in immunocompromised individuals, encounters phosphate limitation during proliferation in phagocytic cells. We therefore tested the hypothesis that phosphate acquisition and polyphosphate metabolism are...

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Identifiers

PMID: 24711572
DOI: 10.1128/IAI.01607-14
PMCID: PMC4097646

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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