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Transcriptional Regulation by Protein Kinase A in Cryptococcus neoformans

13 Mar 2007

Abstract excerpt

A defect in the PKA1 gene encoding the catalytic subunit of cyclic adenosine 5'-monophosphate (cAMP)-dependent protein kinase A (PKA) is known to reduce capsule size and attenuate virulence in the fungal pathogen Cryptococcus neoformans. Conversely, loss of the PKA regulatory subunit encoded by pkr1 results in overproduction of capsule and hypervirulence. We compared the transcriptomes between the pka1 and pkr1...

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PMID: 17367210
DOI: 10.1371/journal.ppat.0030042

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