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Article

Topological localization of monomeric C-reactive protein determines proinflammatory endothelial cell responses.

The Journal of biological chemistry - 16 May 2014

Li Hai-Yun, Wang Jing, Wu Yue-Xin, Zhang Lin, Liu Zu-Pei, Filep János G, Potempa Lawrence A, Wu Yi, Ji Shang-Rong

Abstract excerpt

The activation of endothelial cells (ECs) by monomeric C-reactive protein (mCRP) has been implicated in contributing to atherogenesis. However, the potent proinflammatory actions of mCRP on ECs in vitro appear to be incompatible with the atheroprotective effects of mCRP in a mouse model. Because...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24711458
DOI: 10.1074/jbc.M114.555318
PMCID: PMC4022894

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24711458-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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