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Article

A proteomic analysis of C-reactive protein stimulated THP-1 monocytes

1 Jan 2011

Abstract excerpt

BACKGROUND: C-reactive protein (CRP) is a predictor of cardiovascular risk. It circulates as a pentameric protein in plasma. Recently, a potential dissociation mechanism from the disc-shaped pentameric CRP (pCRP) into single monomers (monomeric or mCRP) has been described. It has been shown that mCRP has strong pro-inflammatory effects on monocytes. To further define the role of mCRP in determining monocyte...

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PMID: 21219634
DOI: 10.1186/1477-5956-9-1

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