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Article

In Vitro Expansion of Human Hepatocytes is Restricted by Telomere-Dependent Replicative Aging

1 Nov 2003

Abstract excerpt

Currently, different techniques to expand human hepatocytes in vitro are being investigated to generate enough cells for liver-directed cell therapies. However, based on observations in fibroblasts and other cell types, telomere attrition limits the proliferative capacity of normal somatic cells. Therefore, we explored whether telomere-dependent replicative aging restricts the in vitro proliferation of human...

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Share to Telomeres, Telomerase, and Senescence
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PMID: 14763510
DOI: 10.3727/000000003771000138

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