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Article

Improving the repopulation capacity of elderly human hepatocytes by decoding aging‐associated hepatocyte plasticity

4 Mar 2022

Abstract excerpt

BACKGROUND AND AIMS: The loss of liver regenerative capacity is the most dramatic age-associated alteration. Because of an incomplete mechanistic understanding of the liver aging process, a successful therapeutic strategy to improve liver regeneration in the elderly has not been developed so far. Hepatocyte plasticity is a principal mechanism for producing new hepatocytes and cholangiocytes during regeneration....

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PMID: 35243665
DOI: 10.1002/hep.32443

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