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Article

Recurrent epimutations activate gene body promoters in primary glioblastoma.

Genome research - 1 May 2014

Nagarajan Raman P, Zhang Bo, Bell Robert J A, Johnson Brett E, Olshen Adam B, Sundaram Vasavi, Li Daofeng, Graham Ashley E, Diaz Aaron, Fouse Shaun D, Smirnov Ivan, Song Jun, Paris Pamela L, Wang Ting, Costello Joseph F

Abstract excerpt

Aberrant DNA hypomethylation may play an important role in the growth rate of glioblastoma (GBM), but the functional impact on transcription remains poorly understood. We assayed the GBM methylome with MeDIP-seq and MRE-seq, adjusting for copy number differences, in a small set of non-glioma CpG island methylator phenotype (non-G-CIMP) primary tumors. Recurrent hypomethylated loci were enriched within a region of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kruppel-Like Transcription Factors

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Share to Zinc Finger Protein Gli3

Source

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Identifiers

PMID: 24709822
DOI: 10.1101/gr.164707.113
PMCID: PMC4009606

Genes

TERT
GLI3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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